Newcastle Falcons’ Chris Harris makes his first start for Scotland after being named at outside centre to face Wales in their Six Nations opener.
Cornell Du Preez starts at number eight, with Ali Price named ahead of fit-again Greig Laidlaw at scrum-half.
Coach Gregor Townsend has made six changes from the side that faced Australia in November.
Stuart Hogg starts at full-back, while Gordon Reid, Jon Welsh, Ben Toolis and Du Preez come into the starting pack.
Scotland starting XV
Stuart Hogg (Glasgow Warriors), Tommy Seymour (Glasgow Warriors), Chris Harris (Newcastle Falcons), Huw Jones (Glasgow Warriors), Byron McGuigan (Sale Sharks), Finn Russell (Glasgow Warriors), Ali Price (Glasgow Warriors), Gordon Reid (London Irish), Stuart McInally (Edinburgh), Jon Welsh (Newcastle Falcons), Ben Toolis (Edinburgh), Jonny Gray, John Barclay (Scarlets, captain), Hamish Watson (Edinburgh), Cornell du Preez (Edinburgh).
Replacements: Scott Lawson (Newcastle Falcons), Jamie Bhatti (Glasgow Warriors), Murray McCallum (Edinburgh), Grant Gilchrist (Edinburgh), Ryan Wilson (Glasgow Warriors), Greig Laidlaw (Clermont Auvergne), Pete Horne (Glasgow Warriors), Sean Maitland (Saracens).